Solution Phase Binding Profiling

Understanding how your molecules engage their targets is critical. However, conventional characterisation tools are slow, expensive, and often require conditions that distort the very interactions you’re trying to measure. 

MolecuNav’s proprietary platform maps the full binding profile of biomolecules (including proteins, peptides, oligosaccharides, and oligonucleotides) in solution, with no cross-linking and no mass spectrometry. A designer molecular tag is attached to the target under investigation; a short series of ¹⁹F NMR titrations then yields precise, quantitative binding parameters for each ligand screened.

What you get: 

• Binding kinetics (Kd, Kon, Koff) for every ligand investigated
• Native solution-phase conditions: no pull-down, no artefacts
• Cross-linking-free and MS-free: faster and lower cost
• Automatable and scalable to fit your discovery timeline

Value proposition:

For drug discovery teams who need fast, quantitative binding characterisation of peptide and protein candidates, MolecuNav delivers solution-phase binding kinetics without mass spectrometry.  This enables higher throughput target engagement studies at a fraction of the time and cost of conventional approaches.